RESEARCH AND MARKET EXPRESS

GLUCOSAMINE SULFATE MAY DELAY OSTEOARTHRITIS

K Pavelká et al., Source: K Pavelká et al., "Glucosamine Sulfate Use and Delay of rogression of Knee Osteoarthritis," Archives of Internal Medicine 162, no. 18 (October 14, 2002): 2113–2123.

Long-term treatment with glucosamine sulfate improves symptoms of knee osteoarthritis and delays progression of the condition, according to researchers.

In a 3-year, randomized, placebo-controlled, double-blind study, researchers gave 202 patients with knee osteoarthritis either a placebo or 1500 mg of glucosamine sulfate per day. The researchers measured changes in tibiofemoral joint space width and assessed joint pain symptoms.

While those receiving the placebo experienced average joint space narrowing of 0.19 mm after three years, average joint space width did not change in those who received glucosamine sulfate. Moreover, symptoms improved only modestly among those taking the placebo, while symptoms improved by 20–25% among those taking the supplement.

"Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification," concluded the researchers.

Early results from the study, which was funded by the Rotta Research/Rottapharm Group, were presented in November 2000 at the annual meeting of the American College of Rheumatology in Philadelphia, and in June 2001 at the annual meeting of the European Congress of Rheumatology in Prague, Czech Republic.
(Published: Archives of Internal Medicine 162, no. 18 (October 14, 2002): 2113–2123 )


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